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Psychiatria Danubina, Vol. 33 No. suppl 4, 2021.

Conference paper

BIOMARKERS OF DEPRESSION ASSOCIATED WITH COMORBID SOMATIC DISEASES

Sandra Uzun ; Department for Anesthesiology, Reanimatology, and Intensive Care, University Hospital Center Zagreb, Zagreb, Croatia
Marina Sagud ; School of Medicine, University of Zagreb, Zagreb, Croatia ; Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Nela Pivac ; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia

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Abstract

Depression is heterogeneous clinical entity with different clinical symptoms, that imply diverse biological underpinning, different
molecular substrates and pathways. Besides different psychiatric comorbidities, depression is frequently interrelated with somatic
diseases. Multi-morbidities, i.e. somatic diseases associated with depression, reduce quality of life, worsen clinical picture and
increase mortality. The most frequent somatic diseases co-occurring with depression are cardiovascular and metabolic diseases.
Vulnerable individuals will develop depression, and the goal in modern research and in precision/personalized medicine is to
determine vulnerability factors associated with development of depression and to find easy available biomarkers of depression,
especially comorbid with somatic diseases. This mini-review aimed to describe the latest published data (from 2015-20120)
considering biomarkers of depression related to somatic diseases. Biomarkers related to inflammatory processes, atherosclerosis,
imbalance of the hypothalamic-pituitary-adrenal axis, autonomic nerve system, sympathetic and parasympathetic nervous system,
heart rate variability and endothelial dysfunction could improve the understanding of the underlying biological mechanisms of the
common pathways of depression comorbid with somatic diseases. These targeted biomarkers might be used to reduce the symptoms,
improve the treatment of these interrelated diseases, and decrease the morbidity and mortality.

Keywords

biomarkers; depression; comorbid somatic disorders; HPA axis; inflammatory response; endothelial dysfunction

Hrčak ID:

271699

URI

https://hrcak.srce.hr/271699

Publication date:

19.10.2021.

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