Original scientific paper
Possible Prognostic Significance of P53 and Ki 67 in Inverted Sinonasal Papilloma
Miljenko Bura
Sven Seiwerth
Ivan Vladika
Darko Perović
Paul Nagy
Marijana Čorić
Lana Bijelić
Zdenko Krajina
Marica Žižić Mitrečić
Abstract
The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma
of the lateral nasal wall and adjacent sinuses regarding their malignant potential and recurrence. 49 biopsies of the lateral
nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically
demonstrated p53 and Ki67 expression was measured and statistically valuated. p53 immunoreactivity
was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated
stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal
papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and,
in case of high Ki67, a hint toward possible recurrence.
Keywords
head and neck tumors; nasal tumors; inverted papilloma; prognostic factors; Ki67; p53
Hrčak ID:
27376
URI
Publication date:
10.4.2007.
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