Conference paper
THE PANDEMIC`S UNRESOLVED INFECTIOUS PSYCHO-NEURO-IMMUNOLOGIES: MYELOID CELLS, VESSELS, NASAL CROSS-ROADS
Gottfried R. S. Treviranus
orcid.org/0000-0001-8859-7259
; BipoSuisse, Vereinsweg 11, CH 3012 Berne, Switzerland
Abstract
Unresolved infectious psycho-neuro-endocrino-inflammation (PNEI) denotes an area of tragically accelerated interest because
of SARS-CoV-2`s capacity to meddle with the immune responses in a stage-wise fashion. Its pandemic, interacting with antecedent
further deteriorating health and living conditions, takes a direct toll of million human lives. In order to withstand the plethora of
slowly or never easing ailments labeled "Post-acute Sequelae of Covid-19 (PASC)" comprehensive understanding from the
intrusions up to its emerging aftermaths is paramount. For the strained health professions these prospect care requirements of 1 in 5
for a non-convalescence overlapping also with other tedious long-hauling triggered disorders adjacent to psychiatry like chronic
fatigue with orthostasis intolerance or intracranial hypertension (ME/CFS-OI; IIH). For the lattter two new pathophysiologies are
proposed in order to inform a strong rehabilitative psychiatric liaison not referring sufferers to a psychiatric "enigmo-somatic bin"
but to an invigorated somato-psychic care e. g. for exertional malaise. Starting from early stimulation of escalating myeloid-derived
suppressor cells the neglected mast cells show up (for now without their lymphatic partners) as ambivalent core participants. They
interact or orchestrate or sequentially explode in etosis guarding or breaking sane barriers especially at cerebral arteries. In Covid-
19 they seem unleashed at the blood-brain-barrier by the early virally invaded nasal ganglia, which plausibly mis-direct the quickest
interstitial arterio-intramural outflow - thus a.) losing its abillity to "comply" wiith pulsatile flow through varying the width of its
sliding chambers causing ME/CFS-Orthostatic Intolerance and b.) inflaming and stiffening the brain's interstitium through a "push-back"
outpacing the confuted inventive "glymphatic-1.0" model.Mast cells - colonized or not - plausibly permeabilize the choroid
plexus and venous or bony brain barriers co-causing the not so rare Idiopathic Intracranial Hypertension. Innate memory - as
activated by short RNAs through BCG-vaccinations directed against the permanent TBC-pandemic leads to hopes for a hastening of
resolutions through a combined medical, exertional, psychosocial, and psychiatric rehabilitation informed by a new "PNEI" -
paving the way for amplified-BCG or future psychiatric vaccinations.
Keywords
SARS-CoV-2; PASC; PNEI; ME/CFS; orthostasis intolerance; IIH; PPG; mast cells
Hrčak ID:
274131
URI
Publication date:
16.9.2021.
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