Review article
https://doi.org/10.20471/may.2022.58.01.12
SARS-Cov2-Induced Cytokine Storm and Schizophrenia, Could There be a Connection?
Pejman Abbasi Pashaki
; Trauma Research Center, Aja University of Medical Sciences, Tehran, Iran
Kiarash Shirbandi
; International Affairs Department (IAD), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,
Sina Ramezani
; Department of Biology, University of Guilan, Rasht, Iran
Fakher Rahim
orcid.org/0000-0002-2857-4562
; Thalassemia and Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Zahra Jamalpoor
; Islamic Azad University, Science and Research Branch, Tehran, Iran
Abstract
Today, a new coronavirus (2019-nCoV, later named SARS-CoV-2) has become known as a pandemic with over 3,949,200 cases and 271,782 deaths. It has been considered that most of the deaths in infected patients stem from comorbidity conditions. Therefore, understanding at-risk populations are currently under the focus of investigations. This object has highly driven attention to put patients with a higher potential of death related to SARS-CoV2 infection at priority. For instance, this can happen in Schizophrenia owing to ambiguous immunology attributes, including elevated levels of pro-inflammatory cytokines and stress-related immune disability. Given that, the hyper-inflammatory responses are the significant cause of the pathophysiology of the SARS-CoV2-related mortality. Moreover, SARS-CoV2 can prompt the risk of developing Schizophrenia in the future. This review punctuates that prenatal/perinatal infection could be associated with increased Schizophrenia risk; on the flip side, the potential risk of ongoing medication can worsen mentally disabled patients, and healthy people are at risk.
Keywords
COVID-19; SARS-CoV-2; inflammation; schizophrenia; olfactory cells
Hrčak ID:
274200
URI
Publication date:
20.3.2022.
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