Review article
(Reactive) Eccrine Syringofibroadenoma with Foci of Squamous Cell Carcinoma in situ: A Case Report
Ivan Franin
; “Ljudevit Jurak” Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Tihana Regović Džombeta
; “Ljudevit Jurak” Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2Department of Pathology, School of Medicine, University of Zagreb, Croatia
Božo Krušlin
; “Ljudevit Jurak” Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2Department of Pathology, School of Medicine, University of Zagreb, Croatia
Davor Tomas
; “Ljudevit Jurak” Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2Department of Pathology, School of Medicine, University of Zagreb, Croatia
Abstract
We describe a rare case of an eccrine syringofibroadenoma
with a foci of squamous cell carcinoma in situ, which has to best of our
knowledge been reported only twice in the English literature. An excisional
biopsy of an elevated, lobular tumor of the lower leg in an 86-yearold
male patient was performed. Histologic examination revealed a tumor
consisting of anastomosing strands of epithelial cells originating
from the epidermis, occasionally showing ductal eccrine differentiation.
Foci of squamous cell carcinoma in situ were observed within the described
lesion. The diagnosis of eccrine syringofibroadenoma with squamous
cell carcinoma in situ was established. Eccrine syringofibroadenoma
is a rare lesion, mostly considered to be a reactive process arising secondarily
in association with other cutaneous diseases such as dermatoses or
neoplasms, although some researchers do not exclude the possibility that
it is a primary neoplasm with a potential for malignant transformation.
Keywords
eccrine syringofibroadenoma, squamous cell carcinoma in situ, immunohistochemistry
Hrčak ID:
274688
URI
Publication date:
15.12.2021.
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