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Veterinary Archives, Vol. 92 No. 1, 2022.

Original scientific paper

https://doi.org/10.24099/vet.arhiv.1319

The influence of chitosan oligosaccharide on some hematological parameters in rats exposed to cadmium

Ihsan Kisadere ; Department of Physiology, Faculty of Veterinary, University of Balıkesir, Balıkesir, Turkey
Mehmet F. Aydin ; Department of Histology and Embryology, Faculty of Veterinary, University of Balıkesir, Balıkesir, Turkey
Hasan H. Dönmez ; Department of Histology and Embryology, Faculty of Veterinary, University of Selcuk, Konya, Turkey

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Abstract

The aim of the study was to investigate the effects of chitosan oligosaccharide (COS) on some hematological
parameters, and define the percentage of alpha-naphthyl acetate esterase (ANAE) positive lymphocytes in rats that had
been exposed to cadmium (Cd). Thirty-two (n = 32) male Wistar albino rats were randomly divided into four groups
as the control (C), chitosan oligosaccharide (COS), cadmium (Cd), and Cd + COS (CdCOS) groups. Blood samples
were collected to assess erythrocytes (RBC), leukocytes (WBC), hemoglobin levels (HGB), hematocrit values (HCT),
mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular
volume (MCV), platelets (PLT), and alpha-naphthyl acetate esterase (ANAE) positive lymphocytes. The number
of WBCs significantly increased in the Cd group compared to the C, CdCOS, and COS groups (P<0.05). Although
the lymphocyte count decreased significantly in the Cd group (P<0.05), it was ameliorated by COS treatment in
the CdCOS group compared to the Cd group (P<0.05). Also, the percentage of peripheral blood ANAE positive
lymphocytes decreased significantly in the CdCOS and Cd groups (P<0.05). COS exhibits a partially protective effect
on some hematological characteristics, apart from the percentage of ANAE positive lymphocyte in cases of chronic
Cd exposure.

Keywords

alpha-naphthyl acetate esterase; cadmium; chitosan oligosaccharides; hematology; rats; toxicit

Hrčak ID:

274815

URI

https://hrcak.srce.hr/274815

Publication date:

24.3.2022.

Article data in other languages: croatian

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