Original scientific paper
https://doi.org/10.3325/cmj.2021.62.25
Non-alcoholic fatty liver disease – a procoagulant condition?
Lucija Virović-Jukić
; Department of Gastroenterology and Hepatology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
Sanja Stojsavljević Shapeski
; Department of Gastroenterology and Hepatology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
Jelena Forgač
; Department of Gastroenterology and Hepatology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
Michal Kukla
; Department of Endoscopy, University Hospital in Krakow, Krakow, Poland
Ivana Mikolašević
; Department of Gastroenterology, School of Medicine, University of Rijeka, Rijeka, Croatia
Abstract
Non-alcoholic fatty liver disease (NAFLD) is associated with
a number of extrahepatic comorbidities and considerable
cardiovascular morbidity and mortality, which is possibly
related to coagulation changes associated with metabolic
syndrome. Coagulation disorders are common in patients
with liver disease of any etiology, and here we review possible alterations in coagulation cascade specific to NAFLD.
We discuss derangements in the coagulation cascade and
fibrinolysis, endothelial dysfunction, and platelet abnormalities as possible culprits for altered coagulation and explore the significance of these changes for potential treatment targets
Keywords
Hrčak ID:
278025
URI
Publication date:
25.2.2021.
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