Original scientific paper
https://doi.org/10.3325/cmj.2021.62.165
The visibility of the periventricular crossroads of pathways in preterm infants as a predictor of neurological outcome and occurrence of neonatal epileptic seizures
Branka Bunoza
; Department of Pediatrics, Division of Pediatric Neurology, University Hospital Center Zagreb, Zagreb, Croatia
Nina Barišić
; University of Zagreb School of Medicine, Zagreb, Croatia
Petra Grđan Stevanović
; Department of Pediatrics, Division of Pediatric Neurology, University Hospital Center Zagreb, Zagreb, Croatia
Ana Bogdanić
; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
Vesna Benjak
; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
Ruža Grizelj
; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
Daniel Turudić
; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
Danko Milošević
; General Hospital Zabok and Hospital of Croatian Veterans, Zabok, Croatia
Marko Radoš
; Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia
Abstract
Aim To evaluate the relationship between the neurological outcome, neonatal epileptic seizures, and signal-intensity visibility of the frontal and parietal periventricular
crossroads of pathways on brain magnetic resonance imaging (MRI) in preterm infants at term-equivalent age.
Methods The study enrolled 48 preterm infants born between 2012 and 2016. The signal-intensity characteristics
of the frontal and parietal periventricular crossroads were
evaluated and classified into four grades. A non-favorable
outcome was defined as a motor and functional disorder
with developmental delay and/or cerebral palsy.
Results Neonatal seizures, epilepsy, pathological EEG and
brain ultrasound finding, and brain MRI abnormalities were
mostly found in neonates with non-favorable outcomes.
Visible frontal and parietal periventricular crossroads were
associated with a normal neurologic outcome (P=0.0004;
P=0.0009, respectively). Not-visible or slightly visible
periventricular crossroads were associated with non-favorable outcomes in the case of frontal crossroads (P=0.036)
and not-visible periventricular crossroads in the case of
both frontal and parietal crossroads (P=0.001, P=0.015, respectively). The visibility of the frontal and parietal periventricular crossroads was associated with a lack of neonatal
epileptic seizures (P=0.03; P=0.02, respectively). The frontal crossroads were more frequently slightly visible, while
the parietal periventricular crossroads were more frequently visible.
Conclusion Poor visibility of the frontal and parietal crossroads of pathways on MRI is associated with neonatal epileptic seizures and poor neurological outcomes in preterm
infants at term-equivalent age
Keywords
Hrčak ID:
278126
URI
Publication date:
29.4.2021.
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