Short communication, Note
https://doi.org/10.3325/cmj.2021.62.264
Plasma levels of soluble TGF ß receptor type III: no apparent promise as a marker in acute pancreatitis
Grgur Salai
; University of Zagreb School of Medicine, Zagreb, Croatia
Marko Zelenika
; Department of Gastroenterology, Dubrava University Hospital, Zagreb, Croatia
Stela Hrkač
; University of Zagreb School of Medicine, Zagreb, Croatia
Vladimir Trkulja
; University of Zagreb School of Medicine, Zagreb, Croatia
Joško Bilandžić
; University of Zagreb School of Medicine, Zagreb, Croatia
Ivica Grgurević
; Division for Liver Diseases, Department of Gastroenterology, Dubrava University Hospital, Zagreb, Croatia
Lovorka Grgurević
orcid.org/0000-0002-9814-3178
; Laboratory of Mineralized Tissues, University of Zagreb School of Medicine, Zagreb, Croatia
Abstract
Aim To assess the potential of the soluble transforming
growth factor β receptor type III (sTGFβrIII), a key regulator
in TGFβ signaling, as a biomarker for diagnosis and stratification of patients with acute pancreatitis (AP).
Methods In this small prospective pilot study, patients’
(N=22) plasma samples were obtained at three time
points: the first and fourth day of hospitalization and the
day of hospital discharge. Healthy controls’ plasma (N=25)
was obtained at a single time point. Concentration of
sTGFβrIII in plasma was determined by ELISA. Data were
analyzed by fitting linear or linear mixed models.
Results Plasma sTGFβrIII levels at presentation (day 1) were
similar in AP patients and healthy participants, irrespectively of the disease severity. sTGFβrIII levels in patients were
constant during hospital stay.
Conclusion These observations do not support further
evaluation of plasma sTGFβrIII levels in this setting, but do
not exclude a potential biological role of TGFβ and membrane-bound TGFβrIII in AP pathophysiology
Keywords
Hrčak ID:
278135
URI
Publication date:
24.6.2021.
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