Psychiatria Danubina, Vol. 34 No. 2, 2022.
Original scientific paper
https://doi.org/10.24869/psyd.2022.273
SERUM CLAUDIN-5, BUT NOT ZONULIN, MAY BE ASSOCIATED WITH OBSESSIVE-COMPULSIVE DISORDER
Faruk Kılıç
; Department of Psychiatry, Süleyman Demirel University Medicine Faculty, Isparta, Turkey
Ümit Işık
; Department of Child and Adolescent Psychiatry, Süleyman Demirel University Medicine Faculty, Isparta, Turkey
Duygu Kumbul Doğuç
; Department of Biochemistry, Süleyman Demirel University Medicine Faculty, Isparta, Turkey
Abstract
Background: The aim of this research was to assess serum zonulin and claudin-5 concentrations to show whether or not their
eventual changes in patients with obsessive-compulsive disorder (OCD) could have etiopathogenetic importance. There was no
research in the literature assessing serum zonulin and claudin-5 levels in OCD to the best of our understanding.
Subjects and methods: In this study, we assumed that there may be a deterioration in serum zonulin and claudin-5 levels in OCD
patients and this may affect the severity of the disease. Thirty-six OCD patients and 35 healthy controls were included in this study.
The patients were administered Hamilton Depression Rating Scale (HDRS) and Yale-Brown Obsession Compulsion Scale (Y-BOCS)
to determine the severity of depression and OCD, respectively. Venous blood samples were collected, and serum zonulin and
claudin-5 levels were measured.
Results: The mean serum claudin-5 level was significantly higher without a significant difference between age, sex, and body
mass index, whereas serum zonulin level was not different from the control group in OCD patients.
Conclusions: In conclusion, the current research indicates that claudin-5 is enhanced in OCD patients and this finding may
contribute to the role of blood-brain barrier in the pathogenesis of OCD.
Keywords
blood-brain barrier; claudin-5; intestinal permeability; zonulin; obsessive-compulsive disorder
Hrčak ID:
280028
URI
Publication date:
5.7.2022.
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