Reumatizam, Vol. 68 No. 1, 2021.
Original scientific paper
https://doi.org/10.33004/reumatizam-68-1-1
Correlation of clinical and histopathological findings in patients with clinically suspected primary Sjögren syndrome
Marija Miletić
; Division of Clinical Immunology, Pulmology and Rheumatology, Department of Internal Medicine, University Clinical Hospital Sestre milosrdnice, Zagreb
Jasenka Markeljević
; School of Medicine, University of Zagreb, Zagreb
Ana Glavina
; Division of Oral Medicine and Paradontology, School of Medicine, University of Split, Split
Ivan Sabol
; Ruđer Bošković Institute, Zagreb
Vinka Vukosav
; Division of Clinical Immunology, Pulmology and Rheumatology, Department of Internal Medicine, University Clinical Hospital Sestre milosrdnice, Zagreb
Fanika Mrsić
; Division of Clinical Immunology, Pulmology and Rheumatology, Department of Internal Medicine, University Clinical Hospital Sestre milosrdnice, Zagreb
Anastasija Barić
; Division of Clinical Immunology, Pulmology and Rheumatology, Department of Internal Medicine, University Clinical Hospital Sestre milosrdnice, Zagreb
Marinka Mravak-Stipetić
; Division of Oral Medicine, University Clinical Hospital Zagreb, Faculty of Dentistry, University of Zagreb, Zagreb
Abstract
Introduction. Association of clinical and diagnostic findings is important in making correct diagnosis in patients with primary Sjogren’s syndrome. The aim of this study was to evaluate the correlation of minor salivary gland biopsy, serological findings and sialometry, as components used to classify primary Sjögren’s syndrome. Materials and methods.Thirty- six patients with subjective symptoms of possible primary Sjögren’s syndrome underwent minor salivary gland biopsy and sialometry. Clinical and laboratory data were retrieved from the clinical files. We compared and correlated biopsy results, serological findings and salivary flow rate between Sjögren and non-Sjögren patients. Patients were classified into two groups, twenty-eight cases (77.8%) had a diagnosis of primary Sjögren’s syndrome and eight cases (22.2%) did not fulfill the classification criteria for diagnosis. Results. Primary Sjögren’s syndrome diagnosis strongly correlated with “positive” biopsy (rho= 0.93, p<0.001), serological findings (rho= 0.38, p=0.023) and negatively correlated with saliva flow rate (rho= –0.51, p=0.002). “Positive” biopsy results were in negative correlation with saliva flow rate (rho= –0.41, p=0.012), but in a stronger correlation with patients below the diagnostic flow rate cutoff (≤0.1 ml/minute, rho= 0.46, p=0.005). Conclusion. In conclusion, unstimulated whole salivary flow rate ≤0.1 ml/minute is highly predictive of “positive” biopsy and can be used as a supplemental method to biopsy in diagnosing the oral component of primary Sjögren’s syndrome.
Keywords
Sjögren’s syndrome; Sialometry; Salivary; Gland; Biopsy; Classification
Hrčak ID:
280230
URI
Publication date:
11.7.2022.
Visits: 915 *