Original scientific paper

https://doi.org/10.20471/acc.2022.61.01.10

Serum Leptin Level in Breast Cancer

Ivan Koprivčić ; Department of Orthopedics and Traumatology, Osijek University Hospital Center, Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ksenija Marjanović ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Pathology and Forensic Medicine, Osijek University Hospital Center, Osijek, Croatia
Anita Matić ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Maja Tolušić Levak ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ivan Lovrić ; Department of Orthopedics and Traumatology, Osijek University Hospital Center, Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Biljana Pauzar ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Surgery, Osijek University Hospital Center, Osijek, Croatia
Ivan Erić ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Surgery, Osijek University Hospital Center, Osijek, Croatia
Vjekoslav Wertheimer ; Department of Orthopedics and Traumatology, Osijek University Hospital Center, Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Abstract

Leptin is a polypeptide which is mostly produced in white fat tissue and is an
important proinflammatory, proangiogenic, proinvasive and mitotic factor. There is ever more evidence
suggesting the key role of leptin in the occurrence of breast cancer. The aim of the study was
to investigate serum leptin levels in patients with benign breast tumors, as well as in various breast
cancer phenotypes, taking into account leptin levels connected to menopausal status and body mass
index (BMI). The study included 97 patients having their breast tumor surgically removed. Serum
leptin level was determined by ELISA method in all study patients. Study results showed that significantly
more women, regardless of having malignant or benign tumors, were postmenopausal and
had a significantly higher level of leptin compared to the premenopausal group. The highest level of
leptin was recorded in the group of postmenopausal obese women compared to other postmenopausal
women but also compared to premenopausal women. According to BMI alone, obese women had a
significantly higher level of leptin regardless of the type of tumor. The most significant differences in
leptin levels observed through BMI were found in the Luminal B1 group. In conclusion, serum leptin
level was shown to be a good diagnostic parameter suggesting a higher possibility of breast cancer
development.

Keywords

Breast cancer; Leptin; Malignant tumor; Menopause; Obesity

Hrčak ID:

280245

URI

https://hrcak.srce.hr/280245

Publication date:

1.3.2022.

Article data in other languages: croatian

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