Original scientific paper

Hemodynamic Differences in Sevoflurane Versus Propofol Anesthesia

Ino Husedžinović
Dinko Tonković
Stjepan Barišin
Nikola Bradić
Stojanka Gašparović

Abstract

The aim of the study was to compare the effect of sevoflurane and propofol anesthesia
on myocardial contractility during laparotomic cholecystectomy using transesophageal
echo-Doppler. In the study, 40 patients were randomized into two groups, depending on
whether they received sevoflurane or propofol anesthesia. Heart rate, cardiac index,
stroke volume, left ventricular ejection time and acceleration were measured 10 minutes
after induction of anesthesia, 1 minute and 25 minutes after incision. The results were
analyzed using paired t-test and ANOVA. Significantly lower values were found for all
parameters after the initial measurement (p<0.05). In the sevoflurane group, stroke volume
decreased from 666.2 ml/beat to 656.4 ml/beat and to 635.6 ml/beat 1 minute
and 25 minutes after incision respectively. In the propofol group changes were from 64
ml/beat to 5810.5 ml/beat to 588.6 ml/beat. Stroke volume was significantly higher
in the sevoflurane than in the propofol group (p<0.05). Sevoflurane anesthesia allows a
better hemodynamic stability during laparotomic cholecystectomy.

Keywords

sevoflurane; propofol; echocardiography; transesophageal; hemodynamics; cholecystectomy

Hrčak ID:

28078

URI

https://hrcak.srce.hr/28078

Publication date:

16.6.2003.

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