Review article
https://doi.org/10.20471/acc.2022.61.s1.12
High-dose Insulin Euglycemic Therapy
Jasmin Hamzić
orcid.org/0000-0003-2726-4308
; Emergency Department, University Hospital Center Zagreb, Croatia
Abstract
Calcium channel blockers and beta-blockers toxicity/poisoning are one of the
most common causes of poisoning. More importantly, they are among the deadliest types of poisoning
caused by cardiac drugs that emergency physicians can encounter. Common toxidrome caused by
these medications includes the following symptoms: hypotension, bradycardia, hypoglycemia/hyperglycemia,
hypothermia, arrhythmia, and seizures. Treatment is usually complex, It consists of administration
of various medications, such as crystalloids, intravenous calcium, glucagon, vasopressors/inotropes,
and especially high-dose insulin euglycemic therapy. In this paper, we will review the mechanism
for this type of treatment, propose a potential protocol for its application and address possible
adverse effects. High-dose insulin euglycemic therapy should be an integral part of the treatment
protocol for calcium channel blockers and beta-blockers toxicity.
Keywords
calcium channel blockers; beta-blockers; toxicity; high-dose insulin euglycemic therapy
Hrčak ID:
281192
URI
Publication date:
1.6.2022.
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