Original scientific paper
Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene – Risk Factor for Coronary Artery Disease in the Tuzla Region Population (Bosnia and Herzegovina
Rifet Terzić
Mitja Letonja
Ibrahim Terzić
Amela Šehić
Muharem Merić
Nataša Teran
Abstract
Angiotensin II is the major effector molecule of renin-angiotensin system; its production
can be conveniently interrupted by angiotensin-converting enzyme (ACE). Typical
plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as
to whether the DD genotype of the ACE polymorphism affects the risk for the development
of coronary artery disease (CAD) and to what extent the ACE polymorphism is associated
with CAD in different populations. We compared the I/D polymorphism in 212
CAD patients younger than 50 years with 165 healthy control individuals. They were all
from the Tuzla region in Bosnia and Herzegovina. Patients with CAD had a higher prevalence
of the DD genotype (36.3%) than controls (25.6%). The odds ratio for the ACE
DD genotype in CAD patients was 1.7 (95% confidence interval 1.0–2.7; p<0.05).We may
conclude that the D/D genotype of the ACE gene polymorphism is associated with an increased
risk for CAD in the Bosnian population.
Keywords
insertion/deletion polymorphism; ACE gene; coronary artery disease; Bosnia and Herzegovina
Hrčak ID:
28201
URI
Publication date:
15.12.2003.
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