Review article
https://doi.org/10.21857/94kl4cl46m
Common pathogenetic factors in metabolic syndrome and dementia
Vesna Lukinovi-Škudar
Vesna Đermanović Dobrota
Goran Šimić
Abstract
Metabolic syndrome (MetS) is characterized by a defined cluster of clinical conditions which include hypertension, impaired glucose tolerance, visceral adiposity and dyslipidemia. Dementia is group of symptoms which have in common deterioration in cognitive function, more than expected from the age of individual, and Alzheimer’s disease (AD) is the most common formo f dementia. Prevalence of both MetS and dementia, including AD, is growing at explosive rate worldwide, both conditions are multifactorial and there is a growing evidence of increased risk of dementia in patients with MetS. In this review, we described the potential underlying role of main components of MetS in the mechanism of pathogenetic changes in dementia. The main pathophysiological factors that contribute to dementia are non-ischemic neurodegeneration and/or neuronal death with accompanying neuroinflamma-
tion, and vascular injury. Specific components of MetS may cause or exaggerate all these changes in individual patient, leading to worsening or accelerating cognitive decline. Better understanding and recognition of the role and mechanism of MetS components as potential underlying factors in demen- tia, is expected to have a beneficial role in prevention and treatment of dementia, as many of MetS components may be influenced on with appropriate change of habits and therapy.
Keywords
metabolic syndrome; vascular complication; diabetic; Alzheimer disease; cognition disorders; dementia
Hrčak ID:
290812
URI
Publication date:
18.12.2022.
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