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Croatian Medical Journal, Vol. 63 No. 3, 2022.

Original scientific paper

https://doi.org/10.3325/cmj.2022.63.244

Influence of genetic substructuring of statistical forensic parameters on genetic short tandem repeat markers in the populations of Southeastern Europe

Natalija Novokmet ; Institute for Anthropological Research, Zagreb, Croatia
Marijana Peričić Salihović ; Institute for Anthropological Research, Zagreb, Croatia
Vedrana Škaro ; DNA Laboratory, Genos Ltd., Zagreb, Croatia
Petar Projić ; DNA Laboratory, Genos Ltd., Zagreb, Croatia
Jelena Šarac ; DNA Laboratory, Genos Ltd., Zagreb, Croatia
Dubravka Havaš Auguštin ; DNA Laboratory, Genos Ltd., Zagreb, Croatia
Pavao Rudan ; Scientific Council for Anthropological Research, Croatian Academy of Sciences and Arts, Zagreb, Croatia
Dragan Primorac ; St. Catherine Hospital, Zagreb, Croatia
Damir Marjanović ; Laboratory for Molecular Anthropology, Center for Applied Bioanthropology, Institute for Anthropological Research, Zagreb, Croatia

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Abstract

Aim To investigate the influence of specific intrapopula
-
tion genetic structures on interpopulation relationships.
Special focus was the influence of island population isola
-
tion on the substructuring of the Croatian population, and
the influence of regional population groups on the sub
-
structuring of Southeast European populations.
Methods Autosomal short tandem repeat (STR) loci were
analyzed by using four forensic parameters: matching
probability (PM), power of discrimination (PD), power of
exclusion (PE), and polymorphic information content (PIC)
on a sample of 2877 unrelated participants of both sexes.
A sample set comprising 590 participants was analyzed for
the first time, and 2287 participants were included from
previous studies. The analysis was performed with Power
-
Stats v. 1.2.
Results The analysis of forensic parameters for all nine loci
in the Croatian subpopulations showed the largest devia
-
tions in the populations of the islands of Korčula and Hvar.
The smallest deviations were found in the mainland popu
-
lation. As for Southeast European populations, the largest
deviations were found in the population of North Mace
-
donia, followed by Romania, Albanians from Kosovo, and
Montenegro, while the smallest deviations were found in
the population of Hungary.
Conclusion The comparison of forensic parameters be
-
tween different subpopulations of Croatia and Southeast
Europe indicates that the isolation of individual Croatian
subpopulations and rare alleles in their gene pool affect
the values of forensic parameters. Specific features of (sub)
populations should be taken into account for appropriate
sampling of the total population when creating a DNA da
-
tabase of STR markers.

Keywords

Hrčak ID:

294596

URI

https://hrcak.srce.hr/294596

Publication date:

23.6.2022.

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