Original scientific paper

https://doi.org/10.20471/acc.2022.61.03.09

Glucosamine Sulfate Efficacy in Treating Knee Osteoarthritis: A Follow-Up Study

Karmela Filipović ; University of Novi Sad, Faculty of Medicine Novi Sad, Serbia Special Hospital for Rheumatic Diseases Novi Sad, Serbia
Jelena Zvekić-Svorcan ; University of Novi Sad, Faculty of Medicine Novi Sad, Serbia Special Hospital for Rheumatic Diseases Novi Sad, Serbia
Cila Demesi Drljan ; University of Novi Sad, Faculty of Medicine Novi Sad, Serbia; Institute of Child and Youth Health Care of Vojvodina, Novi Sad, Serbia
Milan Cvetković ; University of Novi Sad, Faculty of Sport and Physical Education, Novi Sad, Serbia
Dragan Marinković orcid.org/0000-0002-3749-9939 ; University of Novi Sad, Faculty of Sport and Physical Education, Novi Sad, Serbia
Marko Erceg orcid.org/0000-0002-4115-2022 ; University of Split, Faculty of Kinesiology, Split, Croatia

Abstract

Osteoarthritis (OA) can be treated using either a pharmacological or non-pharmacological
approach, or a combination of both. The purpose of the present study was to investigate
the efficacy of crystalline glucosamine sulfate (CGS) in patients with knee OA. This open-label prospective
study (with a 12-month follow-up) included 111 patients of both genders suffering from
knee OA, who attended the Special Hospital for Rheumatic Diseases in Novi Sad, Serbia during
the 2011-2013 period. Patients were divided into the experimental (n=52) and the control (n=59)
group. While the former was prescribed CGS 1500 mg/day, the latter was treated with nonsteroidal
anti-inflammatory drugs (NSAIDs) according to the standard protocol. The efficacy of both treatment
modes was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index
(WOMAC) and Lequesne index, along with the radiological findings which involved knee joint space
width (JSW) measurements. One year following the initial assessment, all patients reported pain
intensity reduction; however, those in the CGS group experienced significantly lower pain intensity
when compared with controls. At the end of the study, no reduction in the progression of joint structure
damage (p>0.5) was noted in either group. Thus, while CGS demonstrated symptomatic efficacy,
it failed to delay the progression of knee OA.

Keywords

Arthritis; Chondroitin; Disease Modifying Drugs; Rehabilitation

Hrčak ID:

296113

URI

https://hrcak.srce.hr/296113

Publication date:

1.11.2022.

Article data in other languages: croatian

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