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Acta clinica Croatica, Vol. 61. No. 4, 2022.

Original scientific paper

https://doi.org/10.20471/acc.2022.61.04.06

Impact of Body Composition on the Quality of Life of Premenopausal Patients with Early Stage Breast Cancer During Chemotherapy

Mirjana Pavlović Mavić orcid id orcid.org/0000-0002-9633-064X ; Sestre Milosrdnice University Hospital Center, University Hospital for Tumors, Zagreb, Croatia
Robert Šeparović orcid id orcid.org/0000-0002-4002-2699 ; Sestre Milosrdnice University Hospital Center, University Hospital for Tumors, Zagreb, Croatia
Ljubica Vazdar orcid id orcid.org/0000-0001-6264-3675 ; Sestre Milosrdnice University Hospital Center, University Hospital for Tumors, Zagreb, Croatia
Ana Tečić Vuger ; Sestre Milosrdnice University Hospital Center, University Hospital for Tumors, Zagreb, Croatia
Marija Banović ; Leptir Polyclinic, Zagreb, Croatia

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Abstract

Body composition has been studied relatively recently as part of oncology trials
in different types of tumors. There are numerous studies that define the impact of chemotherapy side
effects on the quality of life (QoL) of breast cancer patients, however, there are few studies that analyze
the impact of body composition on the QoL of premenopausal patients in the course of cytotoxic
treatment. The study was performed on a sample of premenopausal patients treated with neoadjuvant
or adjuvant AC chemotherapy for early-stage breast cancer at Day Hospital of the Department of
Medical Oncology, University Hospital for Tumors in Zagreb. The study included 68 patients, median
age 46.6 years. Analysis of the QoL questionnaires and their association with body composition indicated
several interesting results. At the beginning of treatment, most pronounced was the connection
between body composition and physical and sexual functioning and hair loss, while in subsequent
treatment cycles the effect on other QoL subdomains, in particular fatigue and diarrhea, was more
pronounced. In conclusion, we found body composition to have a significant impact on certain QoL
subdomains during treatment.

Keywords

Body composition; Quality of life; Breast cancer; Premenopausal women; Chemotherapy

Hrčak ID:

301486

URI

https://hrcak.srce.hr/301486

Publication date:

1.12.2022.

Article data in other languages: croatian

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