Meeting abstract
https://doi.org/10.26800/LV-145-supl2-BS11
The effects of a varying doses of pilocarpine and lithium induced status epilepticus, and treatment with BPC-157
Helen Marie Chiddenton
; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia
Sara Burić
Vlasta Vuković
Abstract
Peptadecapeptide BPC -157 has been reported to have a large spectrum of in vivo activities, from anti-ulcer to central action on the brain dopaminergic system, in addition to the aforementioned, BPC-157 might counteract standard convulsant induced seizures, insulin-, paracetamol-, alcohol withdrawal- and serotonin-syndrome-induced convulsion. The pilocarpine model of temporal lobe epilepsy uses a cholinomimetic convulsant, pilocarpine, to induce status epilepticus; as a result, hippocampal damage occurs thus resulting in the development of spontaneous recurrent seizures. In rats, pilocarpine can be administered with lithium, thus significantly reducing the pilocarpine dose required to induce status epilepticus and resulting in a higher percentage of animals developing status epilepticus.
Keywords
BPC-157; Lithium; pharmacology; pilocarpine; Status epilepticus
Hrčak ID:
303037
URI
Publication date:
23.4.2023.
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