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Veterinary Archives, Vol. 93 No. 3, 2023.

Original scientific paper

https://doi.org/10.24099/vet.arhiv.1737

The efficacy of neutraceuticals to alleviate dog osteoarthritis symptoms, a meta-analysis of case-control trials

Fernando Mata orcid id orcid.org/0000-0002-5687-7114 ; CISAS – Centre for Research and Development in Agrifood Systems and Sustainability, The Polytechnic Institute of Viana do Castelo (IPVC), Viana do Castelo, Portugal
Luisa Dormer ; CISAS – Centre for Research and Development in Agrifood Systems and Sustainability, The Polytechnic Institute of Viana do Castelo (IPVC), Viana do Castelo, Portugal

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Abstract

Osteoarthritis is a common condition in dogs. Non-steroidal anti-inflammatory drugs are currently the most widely used treatment option; however, their chronic use is associated with numerous malefic side effects, including death. There has been increased interest in alternative treatments and nutraceuticals have assumed fundamental importance. A number of individual studies and systematic reviews have been done, but no meta-analysis has been produced to date. By conducting a meta-analysis, we aimed to fill this research gap. We combined the results of 13 case placebo controlled trials in a single major study, to determine the efficacy of nutraceuticals in alleviating symptoms of osteoarthritis. A population of 638 dogs was used, from which 327 were treated with nutraceuticals and 321 were used as controls. A successful random effects model was adjusted (P<0.001), with a risk ratio of 0.62 within a 95% CI of [0.47; 0.81], favouring the use of nutraceuticals. The nutraceuticals used in the trials were green-lipped mussel, chondroitin sulphate, an extract of India and Java turmeric (P54FP), a homeopathic combination preparation known as Zeel®, Ω-3 fatty acids, deep sea fish oil, a mix of glucosamine with chondroitin sulphate and hyaluronic acid, and cannabidiol.

Keywords

case-control trials; dog osteoarthritis; meta-analysis; nutraceuticals; pain relief

Hrčak ID:

307411

URI

https://hrcak.srce.hr/307411

Publication date:

16.8.2023.

Article data in other languages: croatian

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