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Cardiologia Croatica, Vol. 18 No. 9-10, 2023.

Meeting abstract

https://doi.org/10.15836/ccar2023.251

Present and future of calcific aortic valve disease – multiomics approach

Katica Cvitkušić Lukenda orcid id orcid.org/0000-0001-6188-0708 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Marijana Knežević Praveček orcid id orcid.org/0000-0002-8727-7357 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Krešimir Gabaldo orcid id orcid.org/0000-0002-0116-5929 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Blaženka Miškić orcid id orcid.org/0000-0001-6568-3306 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Mario Udovičić orcid id orcid.org/0000-0001-9912-2179 ; University Hospital Dubrava, Zagreb, Croatia
Ana Livun orcid id orcid.org/0000-0002-6758-1677 ; University Hospital Dubrava, Zagreb, Croatia

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Abstract

Keywords

calcific aortic valve disease; multiomics; miRNA

Hrčak ID:

307789

URI

https://hrcak.srce.hr/307789

Publication date:

6.9.2023.

Visits: 415 *

Copyright statement: Croatian Cardiac Society

Copyright: 2023, Croatian Cardiac Society

Date received: 04 August 2023

Date accepted: 13 August 2023

Publication date (print and electronic): August 2023

Volume: 18

Issue: 9-10

Page: 251

Publisher ID: Aortic valve / diagnostic challenges

DOI: 10.15836/ccar2023.251

Article Information (continued)

Categories:

Subject: Extended Abstract

KEYWORDS: :

KEYWORDS:

Keyword: calcific aortic valve disease

Keyword: multiomics

Keyword: miRNA

Present and future of calcific aortic valve disease – multiomics approach

[https://orcid.org/0000-0001-6188-0708] Katica Cvitkušić Lukenda[1][2][*]

[https://orcid.org/0000-0002-8727-7357] Marijana Knežević Praveček[1][2]

[https://orcid.org/0000-0002-0116-5929] Krešimir Gabaldo[1][2]

[https://orcid.org/0000-0001-6568-3306] Blaženka Miškić[1][2]

[https://orcid.org/0000-0001-9912-2179] Mario Udovičić[3]

[https://orcid.org/0000-0002-6758-1677] Ana Livun[3]

 

[1] General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia

[2] Faculty of Dental Medicine and Health Osijek, Osijek, Croatia

[3] University Hospital Dubrava, Zagreb, Croatia

Author notes:

Correspondence to: [*] ADDRESS FOR CORRESPONDENCE: Katica Cvitkušić Lukenda, Opća bolnica “Dr. Josip Benčević” Slavonski Brod, Andrije Štampara 42, HR-35000 Slavonski Brod, Croatia. / Phone: +385-98-556-576 / E-mail: kclukenda@gmail.com

Aortic stenosis (AS) is the most common structural heart disease. The prevalence of calcific aortic valve disease (CAVD) is increasing due to the aging of the population and the pandemic of obesity, diabetes, arterial hypertension, and renal failure. Men are twice as likely to develop AS, and when they do develop the disease, they have significantly more pronounced calcifications (1). The disease is multifactorial, and we still do not understand the processes leading to the onset and progression of CAVD. It can be asymptomatic for many years, but when symptoms occur and no treatment is given, the mortality rate within 2 years is almost 80% (2). Surgical replacement of the aortic valve (AVR) with a mechanical or bioprosthetic prosthesis is the gold standard for the treatment of patients with severe AS. The introduction of transcatheter aortic valve replacement (TAVR) allowed the treatment of high-risk patients, and now the indication has been extended to patients with lower surgical risk. Understanding the regulatory mechanisms involved in the development and progression of the disease appears to be critical to the discovery of biomarkers that could have diagnostic, prognostic, and therapeutic value. According to published research, microRNA is a future biomarker for numerous chronic diseases, including CAVD. Identifying patients prone to calcification could be important in selecting the type of artificial heart valve to be implanted to avoid repeat surgery. Influencing their expression by up- or down-regulation is a challenge of modern molecular biology. An integrated multiomics approach to uncover the pathophysiology of the disease using systems biology techniques and employing (epi)genomics, transcriptomics, proteomics, and metabolomics is now promising in heart valve disease (Figure 1). (3) Combining data from different layers and revealing their communication allows us to understand the molecular mechanisms responsible for CAVD.

FIGURE 1 Calcific aortic valve disease: multiomics approach.
Aorticvalve/diagnosticchallenges-f1

LITERATURE

1 

Goody PR, Hosen MR, Christmann D, Niepmann ST, Zietzer A, Adam M, et al. Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets. Arterioscler Thromb Vasc Biol. 2020 April;40(4):885–900. https://doi.org/10.1161/ATVBAHA.119.313067 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32160774

2 

Nader J, Metzinger L, Maitrias P, Caus T, Metzinger-Le Meuth V. Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management? Noncoding RNA Res. 2020 February 29;5(2):41–7. https://doi.org/10.1016/j.ncrna.2020.02.005 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/32195449

3 

Blaser MC, Kraler S, Lüscher TF, Aikawa E. Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis. Circ Res. 2021 April 30;128(9):1371–97. https://doi.org/10.1161/CIRCRESAHA.120.317979 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33914608

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