Meeting abstract
Diagnostic of premalignant and early malignant laryngeal lesions with narrow band imaging (NBI)
Ana Penezić
; KBC Sestre milosrdnice, Zagre, Hrvatska
Siniša Stevanović
; KBC Sestre milosrdnice, Zagre, Hrvatska
Abstract
Treatment and prognosis of leukoplakia significantly differ with the different pathological types and an
effective examination measure is the key to make informed treatment decision. New diagnostic techniques
with real-time applicability try to better detect or delineate primary squamocellular carcinoma. Narrow band
imaging (NBI) is often called “optical biopsy”, because it enables the characterization of mucosal changes and
making endoscopic findings more predictive without requiring tissue sampling. In detection of surface mucosal
changes characteristic for neoplastic lesions - epithelial abnormalities and vascular changes can be better
observed in NBI. According to the vascular pattern of NBI described by Ni, which is based on the dynamic
changes of the capillary pattern on the surface of vocal cord mucosa and vocal cord leukoplakia were classified
into the following types: type I-III lesions are benign, type IV lesions are precancerous, and type Va-c lesions
are malignant. In University Clinical Hospital Sestre milosrdnice, we conducted a study to show the sensitivity,
specificity and accuracy of NBI in predicting the pathohistological analysis in patients with vocal cord
leukoplakia. During a one-year period, from 39 operated patients with leukoplakia we found 23 patients with
SCC, 6 high grade dysplasia, 8 low grade dysplasia, 2 keratosis. In these cases, NBI sensitivity was 82.14%,
NBI specificity 72.73%, positive predictive value 79.31% (95% CI 60.28% to 92.01%) and negative predictive
value 76.19% (95% CI 52.83% to 91.78%). The accuracy of NBI in our patients was 78%. In conclusion, NBI
is an advanced endoscopic imaging technique that allows early detection of small superficial mucosal lesions
that are undetectable using the conventional white-light endoscopy.
Keywords
Leukoplakia; vocal cord dysplasia; narrow band imaging (NBI); Ni classification
Hrčak ID:
308097
URI
Publication date:
19.9.2023.
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