Original scientific paper
https://doi.org/10.20471/LO.2023.51.02-03.10
Association of blood group a with colorectal cancer prevalence in Croatian population
Matea Vinković
orcid.org/0000-0002-5356-5174
; Research and Development Department, Croatian Institute of Transfusion Medicine (CITM), Zagreb, Croatia and Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Nikolina Parašilovac
orcid.org/0009-0006-8877-3455
; Department of Medical Biochemistry and Laboratory Medicine, Merkur University Hospital, Zagreb, Croatia
Pavica Šonjić
orcid.org/0000-0001-6151-5372
; Clinical Department for Laboratory Diagnostics, Clinical Hospital Center Rijeka, Rijeka, Croatia
Jasna Bingulac-Popović
orcid.org/0000-0002-9449-3154
; Molecular Diagnostics Department, Croatian Institute of Transfusion Medicine (CITM), Zagreb, Croatia
*
Karmela Barišić
orcid.org/0000-0001-9666-5514
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Irena Jukić
; Medical Department, Croatian Institute of Transfusion Medicine (CITM), Zagreb, Croatia
* Corresponding author.
Abstract
Purpose: The aim of our study was to investigate the association of ABO phenotypes and genotypes with colorectal cancer prevalence in Croatian population.
Methods: Study included 80 patients (51 men) with colorectal cancer and 303 healthy volunteer blood donors (180 men) in the control group. Using the PCR-SSP method, genotyping was performed on 5 main alleles (O1, O2, A1, A2, B), resulting in 15 ABO genotypes.
Results: There was no difference in the prevalence of colorectal cancer between men and women. There was no difference in a specific blood group phenotype between patients and healthy controls. However, there was a statistically significant higher odds ratio for individuals to carry blood group A than O in patients with colorectal cancer. There was no significant higher odds ratio for non-O genotypes compared to all genotypes constituting O blood group in patients with colorectal cancer.
Conclusion: Our study has shown that there are higher odds for blood group A in colorectal patients than O when compared to healthy controls, suggesting blood group A could be a potential risk factor for colorectal cancer. This is accordant with some previously published studies. Further studies with larger group of patients and controls are needed to confirm this observation.
Keywords
colorectal neoplasms; ABO blood-group system; blood group antigens
Hrčak ID:
314268
URI
Publication date:
12.2.2024.
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