Original scientific paper

https://doi.org/10.2478/v10007-009-005-z

Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristics

BHUPINDER SINGH ; University Institute of Pharmaceutical Sciences (UGC Centre for Advanced Studies), Panjab University, Chandigarh-160014, India
SONIA PAHUJA ; University Institute of Pharmaceutical Sciences (UGC Centre for Advanced Studies), Panjab University, Chandigarh-160014, India
RISHI KAPIL ; University Institute of Pharmaceutical Sciences (UGC Centre for Advanced Studies), Panjab University, Chandigarh-160014, India
NAVEEN AHUJA ; University Institute of Pharmaceutical Sciences (UGC Centre for Advanced Studies), Panjab University, Chandigarh-160014, India

Abstract

The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose. Response surface plots were drawn and optimum formulations were selected by brute force searches. Validation of the formulation optimization study indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of hydralazine with excellent bioadhesive and controlled release characteristics.

Keywords

hydralazine; experimental design; bioadhesive; response surface methodology; gastrointestinal therapeutic system; hydrophilic matrices

Hrčak ID:

31552

URI

https://hrcak.srce.hr/31552

Publication date:

1.3.2009.

Article data in other languages: croatian

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