Short communication, Note

https://doi.org/10.2478/v10007-009-0004-0

Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents

VEERACHAMY ALAGARSAMY ; Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy-502294, India
DURAIRAJ SHANKAR ; Department of Pharmacy (CARISM), SASTRA University, Tirumalaisamudram, Thanjavur-613 402, India
VISWAS RAJA SOLOMON ; Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
RAJENDRA VASANT SHEOREY ; Department of Pharmacology, Institute of Pharmacy, Raipur Institute of Technology Raipur-492001, India
PERIYASAMY PARTHIBAN ; Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy-502294, India

Abstract

A series of novel 3-cyclohexyl-2-substituted hydrazino-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material, 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one, was synthesized from cyclohexyl amine. Title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic behavior. The compound 3-cyclohexyl-2-(1-methylbutylidene-hydrazino)-3H-quinazolin-4-one (4c) emerged as the most active compound of the series and is moderately more potent in its analgesic and anti-inflammatory activities compared to the reference standard diclofenac sodium. Interestingly, test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid.

Keywords

quinazolin-4(3H)-one; analgesic activity; anti-inflammatory activity; ulcerogenicity

Hrčak ID:

31555

URI

https://hrcak.srce.hr/31555

Publication date:

1.3.2009.

Article data in other languages: croatian

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