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Technologica Acta : Scientific/professional journal of chemistry and technology, Vol. 16 No. 2, 2023.

Original scientific paper

https://doi.org/10.51558/2232-7568.2023.16.2.81

Antimicrobial and cytotoxic activities of essential oil from the aerial parts of Pulicaria dysenterica (L.) Bernh. (Asteraceae)

Ermina Cilović Kozarević orcid id orcid.org/0000-0002-4549-0109 ; Faculty of Pharmacy, University of Tuzla, Tuzla, B&H
Esmeralda Dautović orcid id orcid.org/0000-0002-1250-6581 ; Faculty of Pharmacy, University of Tuzla, Tuzla, B&H
Dalila Halilčević orcid id orcid.org/0000-0001-8497-6104 ; Faculty of Pharmacy, University of Tuzla, Tuzla, B&H
Lamija Kolarević orcid id orcid.org/0009-0002-7409-4735 ; Faculty of Pharmacy, University of Tuzla, Tuzla, B&H
Broza Šarić-Kundalić ; Faculty of Pharmacy, University of Tuzla, Tuzla, B&H
Enida Karić ; Faculty of Pharmacy, University of Tuzla, Tuzla, B&H
Aida Smajlagić ; Faculty of Natural Sciences and Mathematics, University of Tuzla, Tuzla, B&H
Darja Husejnagić ; Faculty of Natural Sciences and Mathematics, University of Tuzla, Tuzla, B&H
Emir Horozić ; Faculty of Technology, University of Tuzla, Tuzla, B&H
Jasmina Glamočlija orcid id orcid.org/0000-0001-6823-1137 ; Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Marina Soković ; Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Jelena Arsenijević ; University of Belgrade - Faculty of Pharmacy, Department of Pharmacognosy, Belgrade, Serbia
Zoran Maksimović orcid id orcid.org/0000-0003-2717-0555 ; University of Belgrade - Faculty of Pharmacy, Department of Pharmacognosy, Belgrade, Serbia

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Abstract

The chemical composition of Pulicaria dysenterica (L.) Bernh. aerial parts essential oil (EO), growing wild in Bosnia and Herzegovina, was presented in the study. Biological activities of the EO was included antimicrobial investigation and cytotoxicity. Antimicrobial activity was determined on selected ATCC strains of microogranisms while cytotoxicity was recorded on HeLa cell line. The aerial parts of P. dysenterica contained 0.3% of yellow, liquid, fragrant EO. The identified 51 constituents accounting for 81.09% of the oil. The EO was characterized by the presence of a high concentration of oxygenated sesquiterpenes 51.83% while oxygenated monoterpenes constituted 15.57%, sesquiterpene hydrocarbons 9.32% and non-terpene compounds presented 4.37% of EO. The dominant compounds were sesquiterpenes caryophyllene oxide, (E)-nerolidol, β-caryophyllene and monoterpene nerol. Antimicrobial activity of EO was tested against bacteria Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, as well as against fungus Candida albicans. Results indicated that all used the microorganisms were sensitive to the EO. It has observed promising results against bacteria Escherichia coli with MIC value 1 x 103 µg mL-1. The oil showed moderate cytotoxicity against HeLa cell line using MTT method with IC50 of 188.52 μg mL-1. These results support traditional use EO in the treatment of diarrhea and dysentery and as insecticide.

Keywords

Pulicaria dysenterica,essential oil,antimicrobial activity,citotoxicity

Hrčak ID:

316817

URI

https://hrcak.srce.hr/316817

Publication date:

27.4.2024.

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