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Rad Croatian Academy of Sciences and Arts. Medical sciences : Medical Sciences, Vol. 563 No. 66-67, 2024.

Review article

Endothelial dysfunction in stroke

Anja Babić ; Clinic of Neurology, Clinical Hospital Center Rijeka, Rijeka, Croatia *
Vita Kormen ; Clinic of Neurology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Vladimira Vuletić ; Clinic of Neurology, Clinical Hospital Center Rijeka, Rijeka, Croatia

* Corresponding author.

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Abstract

The endothelium consists of one layer of endothelial cells which cover the inner layer of the blood and lymph vessels. The endothelium is involved in the regulation of vascular tone and structure, inflammation and thrombosis by releasing various agonistic and antagonistic molecules to maintain homeostasis. Endothelial dysfunction signifies defects of the endothelial cells. Many published studies strongly support the hypothesis that endothelial dysfunction is an essential component of atherosclerosis and its presence is a risk factor for the development of various clinical events, such as stroke. The search for specific biomarkers of endothelial dysfunction can have important clinical significance. Identification and monitoring of biomarkers of endothelial dysfunction could contribute to stroke diagnosis, prognosis and development of therapeutic strategies.

Keywords

biomarkers; blood-brain barrier; endothelial cells; endothelial dysfunction; stroke

Hrčak ID:

318618

URI

https://hrcak.srce.hr/318618

Publication date:

25.6.2024.

Visits: 152 *