Original scientific paper

Responsiveness of duodenal smooth muscle to histamine and carbachol following Escherichia coli infection in chickens

Saka Sanni ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
Patrick Azubuike Onyeyili ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
Usman Bala Shamaki ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria

Abstract

The contractile responses of the duodenal segments from healthy and Escherichia coli infected broiler chickens on exposure to exogenous histamine and carbachol were studied. Molar concentrations of the agonists were introduced into suspensions of the segments in Tyrodes solution at 37 oC and the responses recorded using kymograph. Both healthy and infected segments responded dose-dependently to the agonists. The healthy segments showed greater sensitivity to the agonists and produced significantly (P<0.05) higher mean maximum responses in all cases. The threshold responses to molar concentrations of the drugs were lower for segments from infected chickens. It is suggested that E. coli infection may have altered the contractile responses of chicken duodenum to the agonists.

Keywords

chickens; E. coli; histamine; carbachol

Hrčak ID:

31915

URI

https://hrcak.srce.hr/31915

Publication date:

20.10.2005.

Article data in other languages: croatian

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