Original scientific paper
https://doi.org/10.15644/asc58/3/7
Nonsteroidal Anti-Inflammatory Drugs for Oral Surgery: A Systematic Review and Meta-Analysis
Cristiana Palmela Pereira
; ORENSEMED from UICOB, Faculty of Dental Medicine University of Lisbon, Portugal; Center for Statistics and Applications at the University of Lisbon, Portugal (CEAUL); Faculty of Dental Medicine and the Faculty of Medicine of the University of Lisbon, Portugal.
Madalena Mourão Tropa
; Forensic Analysis Group of the Center for Statistics and Applications at the University of Lisbon, Portugal (CEAUL); Faculty of Dental Medicine University of Lisbon
Rui Santos
; Center for Statistics and Applications at the University of Lisbon, Portugal (CEAUL); School of Technology and Management of the Polytechnic Institute of Leiria, Portugal
Ana Rodrigues
; Forensic Analysis Group of the Center for Statistics and Applications at the University of Lisbon, Portugal (CEAUL); Faculty of Dental Medicine University of Lisbon
Maria de Fátima Brilhante
; Center for Statistics and Applications at the University of Lisbon, Portugal (CEAUL); Faculty of Science and Technology of the University of the Azores
Francisco Azevedo Coutinho
; Faculty of Medicine of the University of Lisbon, Portugal; Stomatology Service at Santa Maria Hospital – Northern Lisbon University Hospital Center, Faculty of Medicine of the University of Lisbon, Portugal
Adriana Resende
; Forensic Analysis Group of the Center for Statistics and Applications at the University of Lisbon, Portugal (CEAUL); Faculty of Dental Medicine University of Lisbon
Diana Augusto
; Forensic Analysis Group of the Center for Statistics and Applications at the University of Lisbon, Portugal (CEAUL); Faculty of Dental Medicine University of Lisbon
Francisco Salvado e Silva
; Faculty of Medicine of the University of Lisbon, Portugal; Stomatology Service at Santa Maria Hospital – Northern Lisbon University Hospital Center, Faculty of Medicine of the University of Lisbon, Portugal
Abstract
Objectives: The aim of the present study was to investigate if there are differences in mitigation acute
pain following oral surgery procedures within a hospital setting and regarding various medication regimens. Materials and methods: A systematic literature search was performed between the years 2013 and 2023, including the databases PUBMED, Cochrane and Scopus, to identify the clinical trials investigating the prescription of non-steroidal (NSAID’s) anti-inflammatory drugs before or after an oral surgery. A meta-analysis with meta-regression model was employed on the primary and secondary outcomes, such as pain, swelling and trismus. Results: Thirty-six articles were included, 6 of them being retrospective and 30 prospective, with a higher proportion of women than men, at a ratio of 1.34:1 and an average age of 31.9 years. Drugs with medium duration of action demonstrated lower values for pain and swelling. Regarding these parameters, pain and swelling, propionic acid derivatives and acetic acid derivatives exhibited lower values respectively. Conclusions: The quality of evidence was low to very low-certainty. The meta-analysis suggests that postoperative pain, swelling and trismus following oral surgery management may be effectively treated with the following drugs: NSAID medium-duration action drugs; propionic acid derivatives for lower pain levels and acetic acid derivatives for lower swelling measures; and Ibuprofen 400mg every 8h for 3 days or less. Clinical
Relevance: Anti-inflammatory and analgesic drugs are prescribed to prevent or treat dental pain. Ibuprofen 400mg was the most prescribed drug after or before an oral surgery procedure. However, the evidence is indirect and needs to be interpreted with caution.
Keywords
Acute Pain; Analgesics; Postoperative Pain; Anti-Inflammatory Agents; Anti-inflammatory; Analgesic; Oral surgery; Postoperative pain
Hrčak ID:
321303
URI
Publication date:
11.10.2024.
Visits: 0 *