Acta clinica Croatica, Vol. 63. No. 1, 2024.
Original scientific paper
https://doi.org/10.20471/acc.2024.63.01.11
Prognostic values of lipid panel data for macrovascular complication development in type 2 diabetic patients with comorbid thyroid dysfunction
Mariya Marushchak
; Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
*
Inna Krynytska
; Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Olena Gashynska
; Department of Medical Prevention Disciplines and Laboratory Diagnostics, Rivne Medical Academy, Rivne, Ukraine
Olena Yakymchuk
; L. Ya. Kovalchuk Surgery N1 with Urology and Minimally Invasive Surgery Department, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
* Corresponding author.
Abstract
This study aimed to evaluate prognostic values of the serum lipid panel data
for development of macrovascular complications (MVC) in patients with type 2 diabetes mellitus
(T2DM) alone and those with comorbid hypothyroidism (HT), diff use non-toxic goiter (DNTG), or
a combination of these disorders. Th e study included 596 inpatients. Receiver operating characteristic
(ROC) analysis was used to identify prognostically signifi cant values of total cholesterol (TC),
triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol
(LDL-C), non-HDL-cholesterol (non-HDL-C) and remnant cholesterol (RC). Th e following cut-off
points that determine the relative risk of MVC development were established: TC >5.11 mmol/L,
TG ≥2.03 mmol/L, LDL-C ≥2.97 mmol/L and non-HDL-C ≥4.29 mmol/L in T2DM patients with
comorbid HT; TC ≥4.97 mmol/L, TG ≥2.54 mmol/L, LDL-C ≥3.21 mmol/L and non-HDL-C
≥4.20 mmol/L in T2DM patients with comorbid DNTG; and TC ≥4.89 mmol/L, TG ≥1.56 mmol/L,
LDL-C ≥2.93 mmol/L, non-HDL-C ≥4.04 mmol/L and RC ≥1.14 mmol/L in those with comorbid
HT and DNTG. Th us, serum levels of TC, TG, LDL-C, non-HDL-C and RC can be used for
stratification of T2DM patients with comorbid thyroid dysfunction into the category of increased risk
of MVC development.
Keywords
Diabetes mellitus type 2; Hypothyroidism; Diffuse non-toxic goiter; Dyslipidemia; Macrovascular complications
Hrčak ID:
322036
URI
Publication date:
1.4.2024.
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