Original scientific paper
https://doi.org/https://doi.org/10.5599/jese.2409
Electrochemical behavior and L-tyrosine sensing properties of nanostructured Cr, Sn and La-doped α-Fe2O3 interfaces
Kanza Maryam
; Sensors and Diagnostics Lab, School of Chemistry, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
Muhammad Umar Javed
; Sensors and Diagnostics Lab, School of Chemistry, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
Chanda Rafique
; Sensors and Diagnostics Lab, School of Chemistry, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
Amir Habib
; Department of Physics, College of Science, University of Hafr Al Batin, PO Box 1803, Hafr Al Batin 39524, Saudi Arabia
Adeel Afzal
orcid.org/0000-0002-6528-7300
; Sensors and Diagnostics Lab, School of Chemistry, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
Abstract
L-tyrosine (Tyr) is a promising biomarker for the diagnosis and monitoring of metabolic disorders and neurodegenerative diseases. This study reports on the electrochemical properties of α-Fe2O3 nanostructures doped with Cr, Sn and La, referred to as CrFeOx, SnFeOx and LaFeOx, respectively, and their application in the enzyme-free electrochemical Tyr sensors. These disposable sensors offer accurate Tyr concentration analysis at room temperature, addressing the limitations of current point-of-care diagnostic methods. The CrFeOx, SnFeOx, and LaFeOx nanostructures serve as selective agents for binding and recognizing Tyr, deposited onto disposable graphite pencil electrodes to form the electrochemical interface. The interfacial resistance, charge-transfer kinetics, mechanism, and reversibility are studied via extensive electrochemical measurements employing electrochemical impedance spectroscopy and cyclic voltammetry. Furthermore, differential pulse voltammetry demonstrates excellent Tyr sensing performance in the concentration range of 0 to 80 μM with 2.65 µA µM-1 cm-2 sensitivity and 360 nM threshold detection limit for the best-performing CrFeOx sensors. Hence, these α-Fe2O3-based sensor systems are practical and efficient for selective Tyr detection, offering potential advancements in personalized healthcare and early disease diagnosis.
Keywords
Metal doped ferric oxide; nonessential amino acid; biomarker; electrochemical sensors; point-of-care testing
Hrčak ID:
323684
URI
Publication date:
7.11.2024.
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