Medicina Fluminensis, Vol. 61 No. 2, 2025.
Review article
https://doi.org/10.21860/medflum2025_330048
Genetic Factors Associated with Posttransplant Diabetes Mellitus (PTDM) in Renal Transplant Patients: A Synthesis of Current Knowledge
Luka Bulić
orcid.org/0000-0001-6522-891X
; University of Zagreb, School of Medicine, Zagreb, Croatia
*
Eva Brenner
; University of Zagreb, School of Medicine, Zagreb, Croatia
Marin Cvitić
; University of Zagreb, School of Medicine, Zagreb, Croatia
Aurora Vareško
; University of Zagreb, School of Medicine, Zagreb, Croatia
Ivana Kraljević
; University Hospital Centre Zagreb, Department of Endocrinology and Diabetology, Zagreb, Croatia
* Corresponding author.
Abstract
Posttransplant diabetes mellitus (PTDM) is a major metabolic complication that can occur after a solid organ transplant. While much about this condition is still unknown, genetic variants have been demonstrated as important factors regarding increased risk of disease development. Based on pathogenic mechanism, these variants can be divided into several categories. These include glucose and lipid metabolism variants (leptin and adiponectin genes), inflammatory response variants (IL-17, CCL2, and CCL5 genes), tacrolimus-related pharmacogenetic variants (CYP3A5 gene), and various metagenomic factors. Renal transplant patients might benefit from optimized therapy and lifestyle, based on the findings of proactive targeted genetic testing.
Keywords
diabetes mellitus; kidney transplantation; polymorphism; genetic; risk factors
Hrčak ID:
330048
URI
Publication date:
1.6.2025.
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