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Cardiologia Croatica, Vol. 20 No. 5-6, 2025.

Meeting abstract

https://doi.org/10.15836/ccar2025.110

Increased body mass could be a risk factor for the development of severe aortic valve stenosis

Karolina Beg orcid id orcid.org/0009-0009-6670-9956 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Sandra Jakšić Jurinjak orcid id orcid.org/0000-0002-7349-6137 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Nevio Aradski orcid id orcid.org/0009-0001-5554-8626 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Katarina Arbanas ; University of Zagreb, School of Medicine, Zagreb, Croatia
Bruno Lekaj orcid id orcid.org/0009-0003-7625-6002 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Laura Mikić orcid id orcid.org/0009-0004-2035-5711 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Vlatka Rešković Lukšić orcid id orcid.org/0000-0002-4721-3236 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Marija Brestovac orcid id orcid.org/0000-0003-1542-2890 ; University Hospital Centre Zagreb, Zagreb, Croatia
Martina Lovrić Benčić orcid id orcid.org/0000-0001-8446-6120 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Joško Bulum orcid id orcid.org/0000-0002-1482-6503 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Zvonimir Ostojić orcid id orcid.org/0000-0003-1762-9270 ; University of Zagreb, School of Medicine, Zagreb, Croatia
Blanka Glavaš Konja orcid id orcid.org/0000-0003-1134-4856 ; University Hospital Centre Zagreb, Zagreb, Croatia
Jadranka Šeparović Hanževački orcid id orcid.org/0000-0002-3437-6407 ; University of Zagreb, School of Medicine, Zagreb, Croatia

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Abstract

Keywords

aortic valve stenosis; body mass index; obesity

Hrčak ID:

330604

URI

https://hrcak.srce.hr/330604

Publication date:

5.5.2025.

Visits: 420 *

Copyright statement: Croatian Cardiac Society

Copyright: 2025, Croatian Cardiac Society

Date received: 16 March 2025

Date: 02 April 2025

Publication date: April 2025

Publication date: April 2025

Volume: 20

Issue: 5-6

Page: 110

Publisher ID: CC 2025 20_5-6_110

DOI: 10.15836/ccar2025.110

Article Information (continued)

Categories:

Subject: Extended Abstract

Categories:

Subject: Scientific abstracts

KEYWORDS: :

KEYWORDS:

Keyword: aortic valve stenosis

Keyword: body mass index

Keyword: obesity

Increased body mass could be a risk factor for the development of severe aortic valve stenosis

[https://orcid.org/0009-0009-6670-9956] Karolina Beg[1]

[https://orcid.org/0000-0002-7349-6137] Sandra Jakšić Jurinjak[1][2][*]

[https://orcid.org/0009-0001-5554-8626] Nevio Aradski[1]

[https://orcid.org/0009-0000-2684-404X] Katarina Arbanas[1]

[https://orcid.org/0009-0003-7625-6002] Bruno Lekaj[1]

[https://orcid.org/0009-0004-2035-5711] Laura Mikić[1]

[https://orcid.org/0000-0002-4721-3236] Vlatka Rešković Lukšić[1][2]

[https://orcid.org/0000-0003-1542-2890] Marija Brestovac[2]

[https://orcid.org/0000-0001-8446-6120] Martina Lovrić Benčić[1][2]

[https://orcid.org/0000-0002-1482-6503] Joško Bulum[1][2]

[https://orcid.org/0000-0003-1762-9270] Zvonimir Ostojić[1][2]

[https://orcid.org/0000-0003-1134-4856] Blanka Glavaš Konja[2]

[https://orcid.org/0000-0002-3437-6407] Jadranka Šeparović Hanževački[1][2]

 

[1] University of Zagreb, School of Medicine, Zagreb, Croatia

[2] University Hospital Centre Zagreb, Zagreb, Croatia

Author notes:

Correspondence to: [*] ADDRESS FOR CORRESPONDENCE: Sandra Jakšić Jurinjak, Klinički bolnički centar Zagreb, Kišpatićeva 12, HR-10000 Zagreb, Croatia. / Phone: +385-1-2388-888 / E-mail: sjaksicj@gmail.com

Introduction: A higher body mass index (BMI) is known to be associated with an increased incidence of aortic valve stenosis (AS). (1,2) We aimed to assess whether obesity is associated with developing severe AS.

Patients and Methods: The study included 548 patients admitted for severe AS from September 2020 to August 2024 at the Heart Valve Department of the University Hospital Centre Zagreb. The mean age of the patients was 78.491 ± 8.347 [30-95], 54% were female and the mean BMI was 27.711 ± 5.020 [15.6-44.4]. They were divided into three groups based on BMI: Group I consisted of severe AS and BMI ≤ 24.9 kg/m2, Group II included BMI 25-29.9 kg/m2, and Group III comprised BMI ≥ 30 kg/m2. For the groups of patients, we analyzed renal function by estimated glomerular filtration rate (eGFR) and standard cardiovascular risk factors: arterial hypertension (AH), diabetes mellitus (DM), smoking, and dyslipidemia (DIS). The presence of other valve involvement, coronary artery disease (CAD) and the intervention (TAVR or SAVR) were also analyzed.

Results: Among 548 analyzed patients with severe AS, most of them (68.1%) were overweight or obese. A total of 160 patients (29.2%) had a BMI ≥ 30 kg/m2 (Group III) and they were overall younger (mean age: 76.225 ± 8.098) compared to the other two groups (P<0.001). The majority of patients in Group III had arterial hypertension (92.5%) and dyslipidemia (79.3%). AH showed a tendency for positive significance (92.5% vs. 91.1% vs. 85.1%, P=0.059). There was no difference in renal function between groups (P=0.708). Despite the lower overall presence of mitral valve regurgitation and stenosis, as well as tricuspid valve regurgitation in obese patients with severe AS (Group III), there was no significance compared to the other two groups (P=0.64, P=0.532, P=0.455). Obese patients had more surgical aortic valve repair (SAVR) than patients with lower BMI (30% vs. 19.2% vs. 16%, P=0.005), probably being overall younger.

Conclusion: This study suggests that among patients with severe aortic valve stenosis, a higher proportion were overweight and obese, indicating that obesity could be a risk factor for the development of severe aortic valve stenosis.

LITERATURE

1 

Kontogeorgos S, Rosengren A, Sandström TZ, Fu M, Lindgren M, Basic C, et al. Association Between Body Mass Index and Risk of Aortic Stenosis in Women in the Swedish Medical Birth Registry. J Am Heart Assoc. 2024 October 15;13(20):e034891. https://doi.org/10.1161/JAHA.123.034891 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/39392145

2 

Sharma A, Lavie CJ, Elmariah S, Borer JS, Sharma SK, Vemulapalli S, et al. Relationship of Body Mass Index With Outcomes After Transcatheter Aortic Valve Replacement: Results From the National Cardiovascular Data-STS/ACC TVT Registry. Mayo Clin Proc. 2020 January;95(1):57–68. https://doi.org/10.1016/j.mayocp.2019.09.027 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/31902429

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