Original scientific paper

https://doi.org/10.20471/acc.2024.63.03-04.29

Relationship of Immunohistochemical Expression of CD86/CD163 Positive Intratumoral Macrophages with Prognosis of Pancreatic Ductal Adenocarcinoma

Goran Glavčić ; Department of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mario Zovak ; Department of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Slavica Sović ; School of Medicine, University of Zagreb, Zagreb, Croatia
Silvija Mašić ; Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Nina Blažević ; Department of Internal medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zvonimir Misir ; Department of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zdenko Bilić ; Department of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Marin Glavčić ; Department of Surgery, Dubrava University Hospital, Zagreb, Croatia
Petra Radulović orcid.org/0000-0002-2902-0297 ; Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia *

* Corresponding author.

Abstract

Recent studies have shown an association of the number of tumor-associated
macrophages (TAM) with the prognosis and treatment outcomes of ductal pancreatic adenocarcinoma.
This study aimed to examine the correlation between CD86 and CD163 macrophage expression
and clinical-pathological characteristics of the disease in patients operated on for pancreatic
carcinoma. A retrospective research was conducted in which the archival materials of the Ljudevit
Jurak Department of Pathology, Sestre milosrdnice University Hospital Center were used together
with all relevant patient clinical data obtained from the Hospital Information System on 76 patients
operated on for pancreatic adenocarcinoma. In our study, the number of CD86 macrophages
and the CD86/CD163 ratio showed a statistically significant correlation with increasing T and N
stages of the disease. The number of CD163 macrophages did not show a statistically significant
correlation with the mentioned variables. These results indicated that in our clinical conditions,
proinflammatory (M1) macrophages were more expressed in locally advanced tumor stages with
worse long-term prognoses. In conclusion, TAMs could be a valid prognostic marker or even a
target for therapeutic agents but more studies will be needed to fully comprehend the impact of
M1/M2 differentiation.

Keywords

Pancreatic adenocarcinoma; M1/M2 macrophages; CD68/CD163; Tumor-associated macrophages; Cancer research; Surgical oncology

Hrčak ID:

333286

URI

https://hrcak.srce.hr/333286

Publication date:

31.12.2024.

Article data in other languages: croatian

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