Professional paper

Current Approach to Keloid Management

Mislav Rončević ; University of Zagreb School of Medicine, Zagreb, Croatia *
Zrinka Bukvić Mokos ; Department of Dermatology and Venereology, University Hospital Centre Zagreb, Zagreb, Croatia
Romana Čeović ; Department of Dermatology and Venereology, University Hospital Centre Zagreb, Zagreb, Croatia
Branka Marinović ; Department of Dermatology and Venereology, University Hospital Centre Zagreb, Zagreb, Croatia
Daška Štulhofer Buzina

* Corresponding author.

Abstract

Keloids are benign skin tumors resulting from deregulated wound
healing processes, characterized by fibroblast hyperactivity, increased collagen
deposition, and resistance to apoptosis. These lesions extend beyond
the original wound borders and often cause significant physical and psychological
burdens, including pain, pruritus, and reduced self-esteem. Despite
advancements in medical science, keloid management remains a challenge
due to the lack of standardized treatment protocols and the high recurrence
rates associated with many therapeutic options. This review examines the efficacy
and limitations of existing treatment modalities, including silicone gel
sheets, antifibrotic agents, intralesional injections, cryotherapy, radiotherapy,
laser therapies, surgical excision, and combination therapies. Emerging approaches,
such as botulinum toxin, antihypertensives, platelet-rich plasma,
and others, are also discussed. This article underscores the need for largescale,
high-quality studies focusing exclusively on keloids to refine treatment
algorithms and advance therapeutic strategies

Keywords

keloids; benign tumors; corticosteroids; cryotherapy; excision

Hrčak ID:

346959

URI

https://hrcak.srce.hr/346959

Publication date:

22.6.2025.

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