Short communication, Note

https://doi.org/10.2478/v10007-009-0017-8

Antioxidant activity of NSAID hydroxamic acids

MARIJANA ZOVKO KONČIĆ ; Faculty of Pharmacy and Biochemistry, UNiversity of Zagreb, Zagreb, Croatia
ZRINKA RAJIĆ ; Faculty of Pharmacy and Biochemistry, UNiversity of Zagreb, Zagreb, Croatia
NEVA PETRIĆ ; Faculty of Pharmacy and Biochemistry, UNiversity of Zagreb, Zagreb, Croatia
BRANKA ZORC ; Faculty of Pharmacy and Biochemistry, UNiversity of Zagreb, Zagreb, Croatia

Abstract

In the present study, seven hydroxamic acid derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen, indomethacin and diclofenac) were found to possess significant antioxidant, radical scavenging and metal chelating activities. The most active antioxidant and radical scavenger was N-methylhydroxamic acid of diclofenac (ANT = 88.0 % and EC50 = 60.1 microg mL-1). The activity of the standard substance, butylated hydroxyanisole, in the two assays was ANT = 86.9 % and EC50 = 18.8 microg mL-1, respectively. Ibuproxam was the strongest iron chelator among investigated hydroxamic acids (EC50 = 255.6 microg mL-1), yet significantly weaker than the standard substance, EDTA (EC50 = 29.1 microg mL-1). It seems that different mechanism is involved in metal chelating activity than in antioxidant and radical scavenging activity. Antioxidant and radical scavenging activities may be connected with conjugation of the nitrogen lone electron pair with the carbonyl group. On the other hand, more hydrophilic substances tend to be better iron chelators.

Keywords

NSAID; hydroxamic acid; antioxidant activity; radical scavenging activity; metal chelating ability

Hrčak ID:

35243

URI

https://hrcak.srce.hr/35243

Publication date:

1.6.2009.

Article data in other languages: croatian

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