Original scientific paper

Anthelmintic screening of fractions of Spigelia anthelmia Linn extracts against experimental Nippostrongylus braziliensis in rats

Olorunfemi Cornelius Jegede ; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria
Rowland Ibrahim Shehu Agbede ; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Joseph Ologunja Ajanusi ; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Ambrose Osematta Adaudi ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria

Abstract

This study was undertaken to screen fractions of extracts of Spigelia anthelmia to fi nd out its anthelmintic activity against experimental Nippostrongylus braziliensis infection in rats. 1000 g of the ethanolic crude extract of Spigelia anthelmia yielded 199 g (19.9%) while fractionation with chloroform, water and ethylacetate yielded 120 g (60%), 64 (32%) and 9 g (4.5%) respectively. In the anthelmintic trial in rats, the aqueous and ethylacetate fractions gave a highly signifi cant (P<0.001) deparasitization; while the chloroform fraction gave non-significant (P>0.05) deparasitization when compared with the control. However, comparing the fractions with each other, chloroform and ethylacetate fractions gave a non signifi cant (P>0.05) deparasitization while the aqueous fraction gave a highly signifi cant (P<0.001) deparasitization. The aqueous fraction was therefore found to possess the active anthelmintic ingredient.

Keywords

Spigelia anthelmia; anthelmintic; Nippostrongylus braziliensis; rats

Hrčak ID:

37428

URI

https://hrcak.srce.hr/37428

Publication date:

20.4.2009.

Article data in other languages: croatian

Visits: 1.862 *