Original scientific paper

https://doi.org/10.2478/v10007-009-0031-x

Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity

NADEEM SIDDIQUI ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
ARPANA RANA ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
SUROOR A. KHAN ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
S. EHTAISHAMUL HAQUE ; Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
M. FAIZ ARSHAD ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India
SHARIQUE Ahmed ; Department of Biochemistry, Faculty of Medicine, 7th October University, Misurata, Libya
WAQUAR AHSAN ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India

Abstract

Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium. Interestingly, all the compounds showed protections against seizures in the range 50-100 % indicative of the promising nature of the compounds against the seizure spread. Compounds 5b and 5c showed complete protection against MES induced seizures.

Keywords

benzothiazole; thiadiazole; anticonvulsant; neurotoxicity; hepatotoxicity

Hrčak ID:

40501

URI

https://hrcak.srce.hr/40501

Publication date:

1.12.2009.

Article data in other languages: croatian

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