Original scientific paper

Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain

NAJIM A. AL-MASOUDI
IMAN A. AL-MASOUDI
IBRAHIM A. I. ALI
YASEEN A: AL-SOUD
BAHJAT SAEED
PAOLO LA COLLA

Abstract

A series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 were assyed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC50 > 1.6 microg mL-1, meanewhile compound 9 exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L-1).

Keywords

amino acids; antitumor activity; antiviral activity; coumarin; coupling reaction

Hrčak ID:

4551

URI

https://hrcak.srce.hr/4551

Publication date:

1.6.2006.

Article data in other languages: croatian

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