Acta Pharmaceutica, Vol. 56 No. 1, 2006.
Short communication, Note
Synthesis and characterization of carbazole derivatives and their antimicrobial studies
ARPUTHARAJ EBENEZER MARTIN
KARNAM JAYARAMPILLAI RAJENDRA PRASAD
Abstract
The reaction of 1-oxo-1,2,3,4-tetrahydrocarbazoles (1a-e) with paraformaldehyde and ethylenediamine yielded N,N'-bis(1,2,3,4-tetrahydrocarbazol-1-ylidene)ethane-1,2-diamines (2a-e). Here, like in another similar attempt of replacing ethylenediamine by ethanolamine, ended up in formation of 2-{[1-(2-(2-aminoethoxy)ethylimino)-1,2,3,4-tetrahydrocarbazol-2-yl-methyl]amino}ethanols (3a-e). These products were characterized by IR, 1H NMR, mass spectra and by elemental analysis. All end products (2a-e, 3a-e) were screened for antibacterial and antifungal activities. The compounds having substituents at C-6 position were found to exhibit pronounced antimicrobial activities.
Keywords
1-oxo-1,2,3,4-tetrahydrocarbazoles; paraformaldehyde; ethylenediamine; ethanolamine; N,N'-bis(1,2,3,4-tetrahydrocarbazol-1-ylidene)ethane-1,2-diamine; 2-{[1-(2-(2-aminoethoxy)ethylimino)-1,2,3,4-tetrahydrocarbazol-2-yl-methyl]-amino}ethanol, antibacterial
Hrčak ID:
4568
URI
Publication date:
1.1.2006.
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