Short communication, Note

https://doi.org/10.2478/v10007-010-0005-z

Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

VIJAY MATHUR ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
RAJESH MUDNAIK ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
LAXMIKANT BARDE ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
ARGHYA ROY ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
UMESH SHIVHARE ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
KISHORE BHUSARI ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India

Abstract

Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000) glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to in vitro drug release by the USP dissolution method, while promising formulations were subjected to in vitro drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by compression method showed more delayed release as compared to formulations prepared by molding method.

Keywords

biodegradable antibiotic implants; glyceryl monostearate; controlled drug release; site delivery; erosion enhancers

Hrčak ID:

48279

URI

https://hrcak.srce.hr/48279

Publication date:

1.3.2010.

Article data in other languages: croatian

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