Acta Pharmaceutica, Vol. 60 No. 2, 2010.
Short communication, Note
https://doi.org/10.2478/v10007-010-0011-1
Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles
Satyajit Dutta
; Department of Pharmacy, IIMT College of Medical Sciences, ‘O’Pocket, Ganga Nagar, Mawana Road, Meerut-250001, Uttar Pradesh, India
Abstract
A series of 2-substituted-4,5-diphenyl imidazoles 1a-j were synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral data. Compounds 1a-j were screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 s and death time of 0.39 to 4.40 s while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 s and death time of 2.16 and 2.47 s, respectively, at the same concentration of 1 % (m/V). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (1b), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (1c), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (1e), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (1g) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (1h) showed significant anthelmintic activity compared to the standard drugs.
Keywords
2-substituted-4,5-diphenyl imidazoles; anthelmintic; antiparasitic
Hrčak ID:
48386
URI
Publication date:
1.6.2010.
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