Original scientific paper
FNA Based Diagnosis of Head and Neck Nodal Lymphoma
Koraljka Gjadrov Kuveždić
; University of Applied Health Studies, Zagreb, Croatia
Igor Aurer
; University of Zagreb, School of Medicine, Zagreb, Croatia
Sunčica Ries
; University of Applied Health Studies, Zagreb, Croatia
Mirna Sučić
; University of Zagreb, School of Medicine, Zagreb, Croatia
Mirjana Marković Glamočak
; Department of Pathology and Cytology, University Hospital Center Zagreb, Zagreb, Croatia
Ivana Ilić
; University of Applied Health Studies, Zagreb, Croatia
Sandra Bašić-Kinda
; Division of Hematology, Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Ivo Radman
; Division of Hematology, Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Boris Labar
; University of Zagreb, School of Medicine, Zagreb, Croatia
Abstract
Fine-needle aspiration (FNA) biopsy has become a well established technique in the diagnosis, staging, and follow-up of patients with head and neck lesions. As in lymphoma diagnostics, FNA serves as a screening method in evaluating potentially affected lymph node for open or core biopsy. According to the World Health Organization classification of lymphoid neoplasms, today it is important to recognize cell morphology and reveal its phenotype, then combine it with different genotypic information and clinical data to provide appropriate therapy. The aim of this study was to assess the efficacy of FNA and immunocytochemistry based lymphoma diagnostic in head and neck region. We conducted a retrospective study during a period of three years where cases with either FNA diagnosis or clinical suspicion of newly recognized or relapsing lymphoma were reviewed. In the study were included patients that were referred to our laboratory from hematology department, in whom head and neck lymphadenopathia was found and lymph node FNA preceded other procedures. Two hundred eighty-five aspirations from 248 patients fulfilled study criteria. Adequate specimens were diagnosed as lymphoma in 100 cases (36%), in 65 male and 35 female patients, 76 in patients with newly discovered disease and 24 in patients with prior lymphoma diagnosis. Overall sensitivity of FNA specimens in the diagnosis of head and neck lymphomas was 90%, specificity 88%, predictive value of a positive result 97%, and predictive value of negative result 61%. Based on our results FNA corroborated with immunophenotyping by immunocytochemistry can be method of choice in primary lymphoma diagnosis as a method complementary to histopathology in lymphoma diagnostics.
Keywords
fine needle aspiration; lymphoma; head and neck; WHO
Hrčak ID:
51233
URI
Publication date:
10.3.2010.
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