Preliminary communication
Parvovirus B 19 (PVB19) Induced Pure Red Cell Aplasia (PRCA) in Immunocompromised Patient after Liver Transplantation
Anna Mrzljak
; University of Zagreb, School of Medicine, Zagreb, Croatia
Ika Kardum-Skelin
; University of Zagreb, School of Medicine, Zagreb, Croatia
Vesna Čolić Cvrlje
; University of Zagreb, School of Medicine, Zagreb, Croatia
Tajana Filipec Kanižaj
; University of Zagreb, School of Medicine, Zagreb, Croatia
Dunja Šušterčić
; Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Denis Guštin
; Department of Surgery, University Hospital »Merkur«, Zagreb, Croatia
Branislav Kocman
; Department of Surgery, University Hospital »Merkur«, Zagreb, Croatia
Abstract
Presented here is a case of human parvovirus B19 (PVB19) induced pure red-cell aplasia (PRCA) in immunocompromised patient after orthotopic liver transplantation (OLT). PVB19 is a small, single-stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA. Post-transplant PRCA is induced either by immunosuppressive agents or PVB19. In the presented case, bone marrow aspiration characterized by the absence of mature erythroid precursors and detection of PVB19 DNA in blood led to treatment with high-dose intravenous human immunoglobulins (IVIG) and subsequent recovery of erythropoiesis. Due to insufficient antibody response in immunocompromised patients, suppression of the PVB19 infection is delayed and repetitive treatments may be administrated in attempt of reversing PRCA.
Keywords
pure red-cell aplasia (PRCA); parvovirus B19 (PVB19); liver transplantation
Hrčak ID:
51277
URI
Publication date:
10.3.2010.
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