Original scientific paper

Concentration of C-reactive protein, magnesium and calcium in children with acute bronchoconstriction before and after therapy with salbutamol

Slavica Dodig orcid.org/0000-0002-3419-5171 ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children's Hospital, Zagreb, Croatia
Ivana Cepelak ; Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Miljenko Raos ; Department for Pulmology and Allergology of infants and small children, Srebrnjak Children's Hospital, Zagreb, Croatia
Renata Zrinski Topic orcid.org/0000-0002-3740-7854 ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children's Hospital, Zagreb, Croatia
Jadranka Zivcic ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children's Hospital, Zagreb, Croatia
Ivan Pavic orcid.org/0000-0003-2670-2003 ; Department for Pulmology and Allergology of infants and small children, Srebrnjak Children's Hospital, Zagreb, Croatia

Abstract

Introduction: In childhood, bronchoobstruction is mostly caused by respiratory viral infections. The aim of this study was to find out possible changes in serum concentration of magnesium and calcium (participants in bronchoconstriction), and concentration of C-reactive protein (marker of inammation) in children with moderate and severe bronchoconstriction, caused by viral respiratory infections.
Materials and methods: The study included 32 children with acute bronchoconstriction caused by a viral respiratory infection. Inhalation of salbutamol was administered according to the severity of bronchoconstriction. Blood sampling was done on admission and the third day of salbutamol administration.
Results: Therapy with salbutamol led to a relief of dyspnea within 36 hours, and symptoms of viral infection have relieved. During follow-up period, magnesium concentration was higher in children with moderate (but not in severe) bronchoconstriction than in healthy children, with consequently higher magnesium to calcium ratio. Concentration of C-reactive protein decreased spontaneously by gradual disappearance of signs and symptoms of viral infection.
Conclusion: Determination of serum magnesium and calcium concentrations and determination of their ratio are not sufficient enough to follow-up on effects of therapy. Additional studies of ionized forms of magnesium and calcium, their intracellular content, as well as concentration in exhaled breath condensate are needed.

Keywords

asthma; bronchoconstriction; calcium; child; C-reactive protein; magnesium

Hrčak ID:

53382

URI

https://hrcak.srce.hr/53382

Publication date:

4.6.2010.

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