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Acta Pharmaceutica, Vol. 60 No. 3, 2010.

Original scientific paper

https://doi.org/10.2478/v10007-010-0026-7

Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis

SANTANU CHAKRABORTY ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
MADHUSMRUTI KHANDAI ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
ANURADHA SHARMA ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
NAZIA KHANAM ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
CH. NIRANJAN PATRA ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
V. JAGANNATH PATRO ; Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India
KALYAN KUMAR SEN ; Department of Pharmaceutics, College of Technological Sciences, West Bengal, India

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Abstract

Ionotropic gelation was used to entrap aceclofenac into algino-pectinate bioadhesive microspheres as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Microspheres were investigated in vitro for possible sustained drug release and their use in vivo as a gastroprotective system for aceclofenac. Polymer concentration and polymer/drug ratio were analyzed for their influence on microsphere properties. The microspheres exhibited good bioadhesive property and showed high drug entrapment efficiency. Drug release profiles exhibited faster release of aceclofenac from alginate microspheres whereas algino-pectinate microspheres showed prolonged release. Dunett's multiple comparison analyis suggested a significant difference in percent inhibition of paw edema when the optimized formulation was compared to pure drug. It was concluded that the algino-pectinate bioadhesive formulations exhibit promising properties of a sustained release form for aceclofenac and that they provide distinct tissue protection in the stomach.

Keywords

algino-pectinate microspheres; aceclofenac; bioadhesion; ionotropic gelation; in vivo study

Hrčak ID:

53496

URI

https://hrcak.srce.hr/53496

Publication date:

1.9.2010.

Article data in other languages: croatian

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