Original scientific paper

https://doi.org/10.2478/v10007-010-0029-4

Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers

DIVYESH H. SHASTRI orcid.org/0000-0002-0968-0749 ; Department of Pharmaceutics, K. B. Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat-382023, India
SHAILESH T. PRAJAPATI ; Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Mehsana, India -384001
LAXMANBHAI D. PATEL ; Director & Professor, C. U. Shah College of Pharmacy & Research, Wadhwan, Gujarat-363030, India

Abstract

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 3336 ºC. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.

Keywords

moxifloxacin hydrochloride; in situ gel; ophthalmic drug delivery; mucoadhesive polymers; 32 full factorial design

Hrčak ID:

53499

URI

https://hrcak.srce.hr/53499

Publication date:

1.9.2010.

Article data in other languages: croatian

Visits: 2.987 *