Original scientific paper
Interactions Between Genetic Variants in Glucose Transporter Type 9 (SLC2A9) and Dietary Habits in Serum Uric Acid Regulation
Iris Jerončić
; Medical School, University of Split, Split, Croatia
Rosanda Mulić
; Medical School, University of Split, Split, Croatia
Zorana Klišmanić
; Medical School, University of Split, Split, Croatia
Diana Rudan
; Clinical Hospital Dubrava, Zagreb, Croatia
Mladen Boban
; Medical School, University of Split, Split, Croatia
Lina Zgaga
; Andrija Štampar School of Public Health, Medical School, University of Zagreb, Zagreb, Craotia
Abstract
Aim To investigate possible interactions between genetic
variants in glucose transporter type 9 (SLC2A9) gene and
dietary habits in serum uric acid regulation.
Methods Participants for this study were recruited from
two isolated Croatian island communities of Vis (n = 918)
and Korčula (n = 898). Three single nucleotide polymorphisms
(SNP) from the SLC2A9 gene (rs1014290, rs6449213,
rs737267) were correlated with dietary habits and uric
acid.
Results A significant decrease in uric acid levels was recorded
with increasing consumption of milk, sour cream,
duck and turkey, and eggs. The only significant interaction
was found between potato consumption and rs737267
and a near-significant interaction was found between soft
drinks and rs1014290 (interaction P = 0.068). Increased
consumption of soft drinks interacting with the TT genotype
at rs1014290 increased serum uric acid. No significant
interactions were observed between food products consumption
and rs6449213.
Conclusion There is a certain extent of interaction between
SLC2A9 and dietary patterns in serum uric acid determination.
The metabolic effect of soft drinks seems to
be determined by the underlying genotype of rs1014290.
Keywords
uric acid; gene-environment interaction; isolate; Vis; Korcula; Croatia
Hrčak ID:
53505
URI
Publication date:
15.2.2010.
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