Veterinary Archives, Vol. 80 No. 2, 2010.
Original scientific paper
Pharmacokinetics and dosage regimen of levofloxacin in buffalo calves after single subcutaneous administration
Data Ram
; Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Vinod K. Dumka
; Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Harpal S. Sandhu
; Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Mukesh Raipuria
; Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Abstract
The present study was conducted on six male buffalo calves to investigate the pharmacokinetics of levofloxacin following a single subcutaneous administration at the dose rate of 3 mg/kg body weight. Appreciable plasma concentration of levofloxacin (0.28 ± 0.01 μg/mL) was detected 2.5 min after injection and the peak plasma level of 2.94 ± 0.07 μg/mL was observed at 1 h. Drug levels of 0.28 ± 0.01 μg/mL in plasma were detected up to 12 h from administration. Rapid absorption of the drug was also evident by the high value of the absorption rate constant (2.53 ± 0.53 /h). The absolute bioavailability of levofloxacin after subcutaneous administration calculated on the basis of AUC (10.5 ± 0.11 μg/mL/h) and Ke (0.272 ± 0.009 /h) after a single intravenous injection in buffalo calves was 44.3 ± 1.76 per cent. The high value of AUC (8.02 ± 0.2 μg/mL/h) reflected major exposure in the buffalo calves. Extensive distribution of the drug into various body fluids and tissues was reflected by the high value of Vdarea (1.06 ± 0.04 L.kg-1). The elimination half-life and MRT were 4.43 ± 0.1 h and 6.71 ± 0.17 h, respectively. On the basis of the pharmacokinetic parameters, the calculated subcutaneous dosage regimen for levofloxacin in buffalo calves was 4.6 mg/kg at 24 h intervals.
Keywords
buffalo calves; dosage; levofloxacin; pharmacokinetics; subcutaneous
Hrčak ID:
56262
URI
Publication date:
26.4.2010.
Visits: 2.887 *